Frank Porreca Selected Research

Pain (Aches)

10/2022	Preclinical assessment of onabotulinumtoxinA for the treatment of mild traumatic brain injury-related acute and persistent post-traumatic headache.
1/2022	A prolactin-dependent sexually dimorphic mechanism of migraine chronification.
1/2022	Dysregulation of serum prolactin links the hypothalamus with female nociceptors to promote migraine.
1/2022	Kappa Opioid Receptor Blockade in the Amygdala Mitigates Pain Like-Behaviors by Inhibiting Corticotropin Releasing Factor Neurons in a Rat Model of Functional Pain.
11/2021	Sexual dimorphism in functional pain syndromes.
11/2021	Chronic Pain Produces Reversible Memory Deficits That Depend on Task Difficulty in Rats.
1/2021	A new hypothesis linking oxytocin to menstrual migraine.
1/2021	A novel, injury-free rodent model of vulnerability for assessment of acute and preventive therapies reveals temporal contributions of CGRP-receptor activation in migraine-like pain.
1/2021	Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial.
1/2021	CGRP monoclonal antibody prevents the loss of diffuse noxious inhibitory controls (DNIC) in a mouse model of post-traumatic headache.

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Frank Porreca Research Topics

Disease

136	Pain (Aches) 10/2022 - 09/2001
85	Hyperalgesia 10/2022 - 05/2002
58	Neuralgia (Stump Neuralgia) 04/2022 - 01/2002
53	Hypersensitivity (Allergy) 01/2022 - 06/2002
43	Chronic Pain 04/2022 - 06/2003
30	Migraine Disorders (Migraine) 01/2022 - 02/2009
14	Inflammation (Inflammations) 01/2021 - 10/2003
11	Headache (Headaches) 10/2022 - 10/2008
10	Secondary Headache Disorders 01/2022 - 03/2010
9	Neoplasms (Cancer) 01/2018 - 01/2005
5	Acute Pain 04/2019 - 05/2006
4	Nervous System Diseases (Neurological Disorders) 01/2022 - 08/2010
4	Peripheral Nerve Injuries 10/2020 - 05/2002
4	Pancreatitis 01/2019 - 06/2006
4	Cancer Pain 10/2015 - 06/2003
4	Tics (Tic) 07/2013 - 02/2003
3	Post-Traumatic Headache 10/2022 - 12/2019
3	Brain Concussion (Cerebral Concussion) 10/2022 - 12/2019
3	Parkinson Disease (Parkinson's Disease) 10/2020 - 09/2011
3	Wounds and Injuries (Trauma) 01/2020 - 06/2003
3	Visceral Pain 01/2019 - 10/2008
3	Bone Neoplasms (Bone Cancer) 01/2018 - 11/2007
3	Breast Neoplasms (Breast Cancer) 01/2018 - 10/2011
3	Postoperative Pain 02/2014 - 02/2009

Drug/Important Bio-Agent (IBA)

61	Opioid Analgesics (Opioids)IBA 07/2021 - 08/2002
30	Morphine (MS Contin)FDA LinkGeneric 07/2021 - 08/2002
29	Analgesics (Analgesic Drugs)IBA 11/2021 - 02/2003
28	Dynorphins (Dynorphin)IBA 04/2022 - 06/2002
25	Pharmaceutical PreparationsIBA 01/2020 - 01/2004
20	LigandsIBA 04/2022 - 06/2004
15	Lidocaine (Xylocaine)FDA LinkGeneric 11/2021 - 06/2002
14	Opioid Receptors (Opioid Receptor)IBA 12/2021 - 06/2004
13	Opiate AlkaloidsIBA 01/2017 - 01/2005
11	Sumatriptan (Imigran)FDA LinkGeneric 01/2022 - 10/2008
11	Dopamine (Intropin)FDA LinkGeneric 01/2022 - 12/2012
10	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2020 - 01/2011
10	Bradykinin Receptors (Bradykinin Receptor)IBA 12/2016 - 12/2006
9	kappa Opioid Receptors (kappa Opioid Receptor)IBA 04/2022 - 12/2016
9	salicylhydroxamic acid (SHAM)IBA 01/2021 - 09/2003
8	Capsaicin (Zostrix)FDA Link 01/2019 - 10/2003
7	Peptides (Polypeptides)IBA 12/2020 - 01/2007
7	Ion Channels (Ion Channel)IBA 10/2020 - 06/2004
7	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2020 - 06/2002
7	Proteins (Proteins, Gene)FDA Link 12/2017 - 08/2007
6	norbinaltorphimineIBA 04/2022 - 07/2017
6	Gabapentin (Neurontin)FDA LinkGeneric 11/2021 - 08/2014
6	Calcitonin Gene-Related PeptideIBA 01/2021 - 02/2009
6	Freund's AdjuvantIBA 12/2016 - 04/2005
6	Clonidine (ST 155)FDA LinkGeneric 05/2015 - 06/2004
6	Ondansetron (Zofran)FDA LinkGeneric 08/2013 - 05/2007
6	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2013 - 12/2002
6	Tryptamines (Triptans)IBA 04/2012 - 10/2008
5	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2012
5	Serotonin (5 Hydroxytryptamine)IBA 11/2019 - 01/2012
5	Substance PIBA 01/2019 - 08/2010
5	Cholecystokinin (Pancreozymin)IBA 01/2012 - 01/2005
5	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 06/2011 - 01/2005
4	(1R,5S)- 4- methyl- 1- propan- 2- ylbicyclo(3.1.0)hex- 3- en- 2- oneIBA 01/2022 - 02/2012
4	Protein Isoforms (Isoforms)IBA 01/2022 - 01/2003
4	ProlactinIBA 01/2022 - 01/2020
4	EnkephalinsIBA 12/2021 - 11/2007
4	CytokinesIBA 01/2021 - 06/2004
4	BradykininIBA 10/2020 - 12/2006
4	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2019 - 04/2012
4	dibutyldichlorotinIBA 01/2019 - 10/2008
4	Dizocilpine Maleate (Dizocilpine)IBA 10/2018 - 11/2002
4	dermorphin-saporinIBA 01/2016 - 06/2002
4	Cholecystokinin B ReceptorIBA 08/2013 - 01/2005
4	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 09/2012 - 08/2010
4	CarrageenanIBA 08/2012 - 10/2003
4	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 09/2011 - 08/2005
4	Sodium Channels (Sodium Channel)IBA 05/2006 - 01/2002
3	Prolactin Receptors (Prolactin Receptor)IBA 01/2022 - 01/2020
3	Naloxone (Narcan)FDA LinkGeneric 07/2021 - 11/2007
3	Biological ProductsIBA 05/2021 - 08/2010
3	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021 - 12/2005
3	Monoclonal AntibodiesIBA 01/2021 - 12/2019
3	NeuropeptidesIBA 01/2020 - 01/2005
3	Nitric Oxide DonorsIBA 01/2020 - 03/2010
3	CannabinoidsIBA 01/2020 - 09/2001
3	Cannabinoid Receptor AgonistsIBA 01/2020 - 02/2003
3	Nerve Growth Factors (Neurotrophins)IBA 01/2019 - 06/2003
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2018 - 06/2004
3	Interleukin-6 (Interleukin 6)IBA 01/2018 - 11/2010
3	Lacosamide FDA Link 12/2017 - 01/2016
3	Semaphorin-3AIBA 12/2017 - 01/2016
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 03/2016 - 06/2004
3	SaporinsIBA 01/2016 - 05/2007
3	Calcium Channels (Calcium Channel)IBA 01/2016 - 04/2011
3	Local AnestheticsIBA 12/2012 - 06/2004
3	Peroxynitrous Acid (Peroxynitrite)IBA 08/2012 - 06/2004
3	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 06/2012 - 09/2003
3	3- (4- t- butylphenyl)- N- (2,3- dihydrobenzo(b)(1,4)dioxin- 6- yl)acrylamideIBA 04/2012 - 04/2005

Therapy/Procedure

48	Therapeutics 01/2022 - 05/2002
39	Ligation 04/2022 - 05/2002
6	Oral Administration 01/2020 - 03/2009
6	Spinal Injections 02/2014 - 06/2004
6	Analgesia 01/2013 - 10/2006
3	Diffuse Noxious Inhibitory Control 01/2021 - 01/2019
3	Drug Therapy (Chemotherapy) 01/2019 - 10/2005